Projects

@article{Mai2025,

title = {Fabrication of Microneedles by Pulsating In Situ Dried Electrostretching for Transdermal Drug Delivery},

author = {N. L. Mai, Y. K. Yong, T. A. Hoang, T. H. Vu, H Vu, V. C. Doan, D. Cai, T. X. Dinh, D. V. Dao, V. T. Dau},

doi = {https://doi.org/10.1002/smtd.202500183},

year  = {2025},

date = {2025-05-07},

urldate = {2025-05-07},

journal = {Small Methods},

abstract = {This paper introduces a novel pulsating in situ dried electrostretching (PIDES) technique for the fabrication of microneedles (MNs) for transdermal drug delivery. This method utilizes pulsed voltage to induce electrohydrodynamic forces that stretch and freeze a polymer droplet into a conical shape with a micrometer-scale tip. With the effects of solvent evaporation, the polymeric droplet is in situ stretched into a conical shape and solidified, transforming into a sharp MN, suitable for transdermal drug administration. Penetration and mechanical tests confirm that the MNs possess sufficient sharpness and strength for effective skin penetration applications. Additionally, curcumin loading and in vitro release tests with different concentrations demonstrate the MNs' ability to carry drugs and exhibit effective controlled release profiles. These findings highlight PIDES as a promising, low-cost, and simple approach for the development of painless and efficient transdermal drug delivery systems.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Ruppert2025,

title = {Modulated-Illumination Intermittent-Contact Tip-Enhanced Raman Spectroscopy},

author = {M. G. Ruppert and B. S. Routley and L. R. McCourt and Y. K. Yong and A. J. Fleming},

url = {https://www.precisionmechatronicslab.com/wp-content/uploads/2025/05/Article.pdf},

doi = {https://doi.org/10.1021/acs.nanolett.4c06397},

issn = {1530-6984},

year  = {2025},

date = {2025-03-13},

urldate = {2025-03-13},

journal = {ACS Nano Letters},

volume = {25},

issue = {14},

pages = {5656-5662},

abstract = {This article presents a proof-of-concept for a new imaging method that combines tip-enhanced Raman spectroscopy with intermittent-contact atomic force microscopy to provide simultaneous nanometer-scale mechanical imaging with chemical contrast. The foremost difference from a standard tip-enhanced Raman microscope is the Raman illumination, which is modulated by the cantilever drive signal so that illumination is only active when the tip is close to the surface. This approach significantly reduces contact forces and thermal damage due to constant illumination while simultaneously reducing background Raman signals. Near-field optical and dynamic cantilever simulations highlight the effect of the imaging parameters on the tip–sample force and the evanescent field enhancement. The experimental images obtained with this new imaging method demonstrate a lateral resolution sufficient to identify single-walled carbon nanotube bundles with a full width at half-maximum of 20 nm.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}