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@article{J25c,

title = {Multivalve Configuration for Soft Robotics: Overcoming the Trade-Off Between Speed and Accuracy in Pneumatic Systems},

author = {T. R. Young and Y. K. Yong and A. J. Fleming},

url = {https://www.precisionmechatronicslab.com/wp-content/uploads/2025/11/young-et-al-2025-multivalve-configuration-for-soft-robotics-overcoming-the-trade-off-between-speed-and-accuracy-in.pdf},

doi = {10.1177/28350111251380262},

issn = {2835-0111},

year  = {2025},

date = {2025-09-29},

urldate = {2025-09-29},

journal = {Robotics Reports},

volume = {3},

number = {1},

pages = {54-64},

abstract = {This article describes a new multivalve configuration for achieving both high speed and high resolution in pneumatically driven soft robotic actuators. The proposed method utilizes dual on/off valves with differing orifice sizes in both the charge and discharge paths of the pneumatic circuit. The multiple-valve arrangement provides five states of flow-rate control, which can provide high flow rate for large step changes in pressure, and fine pressure control for precision positioning or force control. Compared with a proportional valve, the proposed method is physically smaller, lower cost, and significantly faster in charging and discharging a soft actuator. The performance of the proposed multivalve system is evaluated using a dual hysteresis control strategy, where the valve combination is dependent on pressure error. The proposed method is experimentally compared with two single-valve configurations, and the results demonstrate a significant improvement in both speed and accuracy. The proposed method is suited to applications that require a fast response between arbitrary set-points and precise control of position or interaction force.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{nokey,

title = {Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome},

author = {M. Litman and S. Azarpeykan and R. J. Hood and K. Martin and D. Pepperall and D. Omileke and O. Uzun and D. Bhatta and Y. K. Yong and A. Chan and N. Hough and S. Johnson and P. G. Bermejo and F. Miteff and C. G. Esperon and Y. Couch and A. M. Buchan and N. J. Spratt and N. Korin and D. E. Ingber and D. J. Beard},

doi = { https://doi.org/10.1002/advs.202506276},

year  = {2025},

date = {2025-08-13},

urldate = {2025-03-01},

journal = {Advanced Science},

volume = {e06276},

abstract = {In patients with ischaemic stroke, retrograde perfusion of the penumbra by the leptomeningeal collateral vessels (LMCs) is a strong predictor of clinical outcome, thus raising the possibility that enhancing LMC flow could offer a novel therapeutic approach. Here, using computational modelling we show that LMCs experience elevated fluid shear stress that is significantly higher than that in other blood vessels during ischaemic stroke in animals and humans. We take advantage of this to selectively enhance flow in LMCs using shear-activated nanoparticle aggregates carrying the vasodilator nitroglycerin (NG-NPAs) that specifically release drug in regions of vessels with high shear stress (≥100 dyne/cm2). The NG-NPAs significantly increased LMC-mediated penumbral perfusion, decreased infarct volume, and reduced neurological deficit without altering systemic blood pressure in a rat ischaemic stroke model. The NG-NPAs also did not cause known common side effects of systemic nitrate administration, such as systemic hypotension, cerebral vascular steal, cortical vein dilation, or intracranial pressure elevation. Systemic administration of free NG at the maximal tolerated dose, which was ten times higher than the dose of NG used in the NG-NPAs, did not enhance LMC perfusion and dropped blood pressure. Thus, packaging NG within shear-activated NPAs can potentially enable this widely available vasodilator to become a highly effective therapeutic for ischaemic stroke.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}