Publications

@proceedings{Mai2025c,

title = {Pulsated in-Situ Dried Electrostretching Fabrication of Microneedles for Transdermal Drug Delivery},

author = {N. L. Mai and T. A. Hoang and T. H. Vu and H. D. Vu and C. Doan and Y. K. Yong and T. X. Dinh and D. V. Dao and V. T. Dau},

doi = {10.1109/Transducers61432.2025.11110014},

year  = {2025},

date = {2025-06-29},

abstract = {This paper reports a pioneering technique to fabricate microneedles (MNs) for transdermal drug delivery utilizing pulsated in-situ dried electrostretching (PIDES). This approach applies pulsed voltage to generate electrohydrodynamic forces that stretch and solidify a polymer droplet into a conical shape with a micrometer-scale tip. As the solvent evaporates, the polymer droplet is stretched in-situ into a cone and hardens, forming a sharp MN ideal for transdermal drug delivery. Penetration and mechanical tests confirm that the MNS have the necessary sharpness and strength for effective skin penetration. Furthermore, curcumin loading and a release test show that the MNS can effectively carry drugs and provide a gradual release of drug. These results demonstrate that PIDES is a promising, cost-effective, and straightforward method for developing efficient and painless transdermal drug delivery systems.},

howpublished = {23rd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)},

keywords = {Electrohydrodynamics, Electrostretching, Microneedles, Pulsed voltage},

pubstate = {published},

tppubtype = {proceedings}

}